This paper introduces RoboRun, a mobile-robot runtime that dynamically exploits the compute-environment synergy to improve performance and energy. We implement RoboRun in the Robot Operating System (ROS) and evaluate it on autonomous drones. We compare RoboRun against a state-of-the-art static design and show 4.5X and 4X improvements in mission time and energy, respectively, as well as a 36% reduction in CPU utilization.